Angels in America (2003) 
Playwright Tony Kushner adapts his political epic about the AIDS crisis during the mid-eighties, around a group of separate but connected individuals.
Angels in America: Millennium Approaches Season 1, Episode 1
It is 1985, Ronald Reagan is in the White House, and AIDS is causing mass death in the Americas. In Manhattan, Prior Walter tells Louis, his lover of four years, that he has AIDS; Louis, unable to handle it, leaves him. As disease and loneliness ravage Prior, guilt invades Louis. Joe Pitt, a Mormon and Republican attorney, is pushed by right-wing fixer Roy Cohn toward a job at the US Department of Justice. Both Pitt and Cohn are in the closet: Pitt out of shame and religious turmoil, Cohn to preserve his power and image. Pitt's wife Harper is strung out on Valium, causing her to hallucinate constantly (sometimes jointly with Prior during his fever dreams) and she longs to escape from her sexless marriage. An angel with ulterior motives commands Prior to become a prophet.
(Description from Wikipedia)