Fullmetal Alchemist: Brotherhood 
Two brothers search for a Philosopher's Stone after an attempt to revive their deceased mother goes awry and leaves them in damaged physical forms.
Fullmetal Alchemist: Brotherhood: Full Series Discussion All Seasons
Brothers Edward and Alphonse Elric search for the Philsopher's Stone, hoping to restore their bodies, which were lost when they attempted to use their skills to perform a taboo in alchemy. [more inside]