Marvel's M.O.D.O.K. (2021-) 
It centers around an egomaniacal supervillain with a really big head and a really little body, who struggles to maintain control of his evil organization and his demanding family.
Marvel's M.O.D.O.K.: Full Season Season 1 (Full Season)
In this adult animated sitcom, a Mental Organism Designed Only for Killing must balance his work and family life. Starring Patton Oswalt. [more inside]